Angioedema with severe acute abdominal pain: Think of hereditary angioedema

Nayla Mumneh; Matthew Tick; Marie Borum

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Angioedema with severe acute abdominal pain: Think of hereditary angioedema

机译：Angioedema with severe acute abdominal pain: Think of hereditary angioedema

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Angioedema can be either mast cell-(histamine-)mediated or bradykinin-mediated. Treatment approaches for the two types are very different, making differential diagnosis critical. Severe acute abdominal pain caused by intestinal angioedema is commonly misdiagnosed, especially when associated with bradykinin-mediated angioedema. After describing a typical clinical scenario and diagnostic journey of a patient with recurrent, undiagnosed abdominal pain due to hereditary angioedema (HAE), a rare variant of bradykinin-mediated angioedema, we delve into the classification and differential diagnosis of the various types of angioedema and provide an overview of appropriate management with an emphasis on the bradykinin-mediated types. Bradykinin-induced angioedema may be inherited or acquired and is infrequent compared to mast cell-mediated angioedema. HAE is a rare disease characterized by recurrent attacks of non-urticarial, nonpruritic edema usually affecting the face, respiratory tract, extremities, gastrointestinal tract, and genitalia. Unlike mast cell-mediated angioedema, painful abdominal symptoms are prevalent in bradykinin-mediated angioedema and are sometimes the only manifestation of an attack, increasing the likelihood of initial misdiagnosis as appendicitis or other forms of acute abdomen. It is important for gastroenterologists to be vigilant for the possibility of angioedema pathology in patients presenting with undiagnosed, recurrent, abdominal symptoms to facilitate accurate diagnosis and effective treatment.

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《Clinics and research in hepatology and gastroenterology.》 |2021年第4期|101702-101702|共1页
作者
Nayla Mumneh; Matthew Tick; Marie Borum;
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作者单位

Medical Director Respiratory, Novartis Pharmaceuticals Corp, 1 Health Plaza, East Hanover, NJ;

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原文格式 PDF
正文语种英语
中图分类消化系及腹部疾病;
关键词
Hereditary angioedema; Intestinal angioedema; Acute abdominal pain; C1-INH deficiency; Bradykinin mediated;

Angioedema with severe acute abdominal pain: Think of hereditary angioedema

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