Gadolinium (Ⅲ)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

Xiangyu Chen; Shiyong Teng; Jinming LiXuezhi QiaoWeidong ZhaoZhengjie XueXudong ShiYuguang WangWensheng YangTie Wang

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Gadolinium (Ⅲ)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

机译：Gadolinium (Ⅲ)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

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Magnetic resonance imaging (MRI) contrast agents, such as Magnevist(Gd-DTPA), are routinely used for detecting tumors at an early stage.However, the rapid clearance by the kidney of Gd-DTPA leads to short bloodcirculation time, which limits further improvement of the contrast betweentumorous and normal tissue. Inspired by the deformability of red bloodcells, which improves their blood circulation, this work fabricates a novelMRI contrast agent by incorporating Gd-DTPA into deformable mesoporousorganosilica nanoparticles (D-MON). In vivo distribution shows that thenovel contrast agent is able to depress rapid clearance by the liver andspleen, and the mean residence time is 20 h longer than Gd-DTPA. TumorMRI studies demonstrated that the D-MON-based contrast agent is highlyenriched in the tumor tissue and achieves prolonged high-contrast imaging.D-MON significantly improves the performance of clinical contrast agentGd-DTPA, exhibiting good potential in clinical applications.

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来源
《Advanced Materials》 |2023年第20期|2211578.1-2211578.9|共9页
作者
Xiangyu Chen; Shiyong Teng; Jinming LiXuezhi QiaoWeidong ZhaoZhengjie XueXudong ShiYuguang WangWensheng YangTie Wang;
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作者单位

Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384, P. R. China, State Key Laboratory of Inorganic Synthesis and Preparative ChemistryCollege of ChemistryJilin UniversityChangchun 130022, P. R. China, Beijing Nati;

State Key Laboratory of Inorganic Synthesis and Preparative ChemistryCollege of ChemistryJilin UniversityChangchun 130022, P. R. China;

Beijing National Laboratory for Molecular SciencesKey Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences CASBeijing 100049, P. R. ChinaLife and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384, P. R. China, Beijing National Laboratory for Molecular SciencesKey Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal SciencesPeking Union Medicine CollegeChinese Academy of Medical SciencesBeijing 100021, P. R. ChinaCenter of Digital DentistryPeking University School and Hospital of Stomatology NHC ResearchCenter of Engineering and Technology for Computerized DentistryBeijing 100081, P. R. China;

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blood circulation; contrast agent; deformable nanocarriers; magnetic resonance imaging;

Gadolinium (Ⅲ)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

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