Prior ablation and progression of disease correlate with higher tumor-to-normal liver Tc-99m-MAA uptake ratio in hepatocellular carcinoma

Patel Mikin V; McNiel David; Brunson ChristopherKuo Phillip H.Hennemeyer Charles T.Woodhead GregoryMcGregor Hugh

首页> 外文期刊>Abdominal radiology. >Prior ablation and progression of disease correlate with higher tumor-to-normal liver Tc-99m-MAA uptake ratio in hepatocellular carcinoma

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Prior ablation and progression of disease correlate with higher tumor-to-normal liver Tc-99m-MAA uptake ratio in hepatocellular carcinoma

机译：Prior ablation and progression of disease correlate with higher tumor-to-normal liver Tc-99m-MAA uptake ratio in hepatocellular carcinoma

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Purpose Factors affecting tumor-to-normal tissue ratio (T:N) have implications for patient selection, dosimetry, and outcomes when considering radioembolization for HCC. This study sought to evaluate patient, disease specific, and technical parameters that predict T:N as measured on planning pre-Y-90 radioembolization Tc-99m-MAA scintigraphy for hepatocellular carcinoma (HCC). Methods Tc-99m-MAA hepatic angiography procedures with SPECT/CT over a 4-year period were reviewed. Data recorded included patient demographics, details of underlying liver disease, tumor size, history of prior treatments for HCC and technical parameters from angiography. Anatomic-based segmentation was performed in 93 cases for measurement of tumor and perfused liver volumes and SPECT counts. T:N were calculated and correlated with collected variables. Results Mean calculated T:N was 2.52. History of prior ablation was significantly correlated with higher T:N (mean 3.39 vs 2.24, p = 0.003). Cases in which mapping was being performed for treatment of disease progression was significantly correlated with higher T:N (mean 3.35 vs 2.14, p = 0.001). Larger tumor size trended toward lower T:N (p = 0.052). Conclusion Patients with history of ablation and those undergoing treatment for disease progression have higher T:N and, therefore, could be considered for radioembolization preferentially over alternative treatments.

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《Abdominal radiology.》 |2023年第2期|752-757|共6页
作者
Patel Mikin V; McNiel David; Brunson ChristopherKuo Phillip H.Hennemeyer Charles T.Woodhead GregoryMcGregor Hugh;
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University of Chicago,Univ Chicago;

Dept Med Imaging,Univ Arizona;

Dept Radiol,Univ Washington Med;

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正文语种英语
中图分类内科学;
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Radioembolization; Dosimetry; Hepatocellular carcinoma; Interventional oncology; INTERNAL RADIATION-THERAPY; GLASS MICROSPHERES; Y-90 RADIOEMBOLIZATION; PREDICTIVE DOSIMETRY; RESIN MICROSPHERES; SURVIVAL; MULTICENTER; HYPOXIA;

Prior ablation and progression of disease correlate with higher tumor-to-normal liver Tc-99m-MAA uptake ratio in hepatocellular carcinoma

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