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外文期刊>Experimental dermatology.
>Partial Epithelial-Mesenchymal Transition: Reduced miR-4792 and miR-146b-5p Inversely Correlated with SIAH2 in Migrating Keratinocytes in Vitro
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Partial Epithelial-Mesenchymal Transition: Reduced miR-4792 and miR-146b-5p Inversely Correlated with SIAH2 in Migrating Keratinocytes in Vitro
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机译：Partial Epithelial-Mesenchymal Transition: Reduced miR-4792 and miR-146b-5p Inversely Correlated with SIAH2 in Migrating Keratinocytes in Vitro
There is a paucity of diagnostics and biological therapeutics available to treat chronic wounds. Improving diagnosis and treatment of wounds rests on a thorough understanding of the physiological and molecular mechanisms that regulate wound healing. During the re-epithelialisation stage of wound healing, a partial epithelial-mesenchymal transition (pEMT) occurs in wound-edge keratinocytes. Here, sedentary and firmly cohesive keratinocytes respond to injury by reducing their interconnections and initiating migration over the wound bed to bring about wound closure.1 MicroRNAs (miRs) regulate pEMT during cancer metastasis, usually through translational repression, and are likely to regulate wound-edge pEMT. We sought to understand miR contribution to the pEMT of re-epithelialisation by measuring changes in miR levels and their target genes in a wound model in which wound-edge cells were isolated from edge-distal cells, for comparison.
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