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首页> 外文期刊>Journal of orthopaedic research >Enhanced Subchondroplasty Treatment for Post‐Traumatic Cartilage and Subchondral Bone Marrow Lesions in a Canine Model
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Enhanced Subchondroplasty Treatment for Post‐Traumatic Cartilage and Subchondral Bone Marrow Lesions in a Canine Model

机译：Enhanced Subchondroplasty Treatment for Post‐Traumatic Cartilage and Subchondral Bone Marrow Lesions in a Canine Model

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ABSTRACT This study characterizes outcomes associated with subchondroplasty (SCP) versus SCP enhanced with platelet‐rich plasma (PRP) or bone marrow aspirate concentrate (BMC) treatment of impact‐induced subchondral bone marrow lesions (BML) using a validated preclinical canine model. With IACUC approval, purpose‐bred research hounds (n?=?24) underwent arthroscopic impact injury (40?N) to both medial femoral condyles. At 3 months, functional assessments, arthroscopy, and magnetic resonance imaging (MRI) were performed. One knee in each dog (n?=?24; n?=?12 per endpoint) was randomly assigned to SCP with the other knee randomly assigned to SCP?+?PRP, SCP?+?BMC or sham injection (control) (n?=?8 per group; n?=?4 per endpoint). Dogs were evaluated at 6 and 12 months after treatment using functional assessments, radiography, arthroscopy, and MRI and humanely euthanatized at 6 or 12 months after treatment for histologic assessments. At 6 months post‐treatment, comfortable range‐of‐motion (CROM) was higher (p?

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