Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers

N. Pueyo; J.B. Navarro; M. Fatjó-VilasN. de la OsaE. PeneloL. FañanásL. Ezpeleta

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Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers

机译：Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers

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Background and Objectives From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene ( MAOA -uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA -uVNTR results in differential enzyme activity, so that high-activity alleles ( MAOA -H) are linked to reduced dopamine, serotonin, and norepinephrine availability in comparison to low-activity allele ( MAOA -L). As MAOA -uVNTR has been previously described to moderate the relationship between childhood parental maltreatment and aggressive and antisocial behavior, it may also play a role in CU traits etiology. Methods Data was collected through questionnaires answered by parents and teachers. MAOA -uVNTR was genotyped in 368 Caucasian children from a community sample (51.9% male). Multiple linear regression analyses were conducted to analyze the interaction effect of MAOA genotypes and both positive parenting and punitive parenting practices on CU traits at two different periods (3 and 5 years old) and separately by sex. Results No significant interactions were found for boys. Among girls, a significant interaction effect was found for MAOA -LL carriers, who showed higher CU traits at age 5 when exposed to higher punitive or positive parenting at age 3. Conclusions Our study provides the first evidence for significant MAOA × early parenting effects on CU traits in preschoolers, specifically among female MAOA -LL carriers. This suggests that the MAOA -LL genotype for girls is associated with higher sensitivity to both positive and punitive parenting in girls, so that MAOA -LL emerges as a genotype that confers higher vulnerability to parental influences.

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《The European journal of psychiatry.》 |2021年第4期|225-233|共9页
作者
N. Pueyo; J.B. Navarro; M. Fatjó-VilasN. de la OsaE. PeneloL. FañanásL. Ezpeleta;
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Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona;

Departament de Psicobiologia i de Metodologia de les Ciències de la Salut, Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Universitat Autònoma de Barcelona;

Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de BarcelonaDepartament de Psicologia Clínica i de la Salut, Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Universitat Autònoma de BarcelonaDepartament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona;

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正文语种英语
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Callous unemotional traits; Development; Gene by environment; MAOA; Parenting practices; Preschool;

Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers

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