Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

Christian M. Gill; Elif Aktas; Wadha AlfouzanLori BourassaAdrian BrinkCarey-Ann D. BurnhamRafael CantonYehuda CarmeliMarco FalconeCarlos KifferAnna MarcheseOctavio MartinezSpyros PournarasHarald SeifertAbrar K. ThabitMaria Virginia Villegasp Lars F. WestbladeDavid P. Nicolauon behalf of the ERACE-PA Global Study Group

首页> 外文期刊>Antimicrobial agents and chemotherapy. >Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

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Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

机译：Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

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The present study evaluated the in vitro potency of ceftazidime and cefe-pime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints.

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《Antimicrobial agents and chemotherapy.》 |2021年第11期|e01204-e01221|共18页
作者
Christian M. Gill; Elif Aktas; Wadha AlfouzanLori BourassaAdrian BrinkCarey-Ann D. BurnhamRafael CantonYehuda CarmeliMarco FalconeCarlos KifferAnna MarcheseOctavio MartinezSpyros PournarasHarald SeifertAbrar K. ThabitMaria Virginia Villegasp Lars F. WestbladeDavid P. Nicolauon behalf of the ERACE-PA Global Study Group;
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Center for Anti-Infective Research & Development, Hartford Hospital, Hartford, Connecticut, USA;

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正文语种英语
中图分类治疗学;
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Pseudomonas aeruginosa; carbapenem resistance; cefepime; ceftazidime; pharmacodynamics; pharmacokinetics;

Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

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