Antioxidase-Like Nanobiocatalysts with Ultrafast and Reversible Redox-Centers to Secure Stem Cells and Periodontal Tissues

Jiusi Guo; Zhenyu Xing; Luchang LiuYimin SunHongju ZhouMingru BaiXikui LiuMohsen AdeliChong ChengXianglong Han

首页> 外文期刊>Advanced functional materials >Antioxidase-Like Nanobiocatalysts with Ultrafast and Reversible Redox-Centers to Secure Stem Cells and Periodontal Tissues

【24h】

Antioxidase-Like Nanobiocatalysts with Ultrafast and Reversible Redox-Centers to Secure Stem Cells and Periodontal Tissues

机译：Antioxidase-Like Nanobiocatalysts with Ultrafast and Reversible Redox-Centers to Secure Stem Cells and Periodontal Tissues

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Exploration of efficient antioxidase-like reactive oxygen nanobiocatalysts(ROBCs) is a major challenge in combating oxidative stress-related diseases.Herein, the molecularly well-defined Ru-porphyrin-networks (Ru-Por-Net)-basedROBCs with ultrafast and reversible redox-centers for catalytic elimination ofreactive oxygen species (ROS) are reported. Owing to the large π-conjugatednetworks, Ru–N coordination structures, and unique electronic and redoxproperties of atomic Ru sites, the Ru-Por-Net-based ROBCs exhibit exceptionalcatalytic ROS-scavenging activities. It is considerably more efficient thanrecently reported state-of-the-art anti-ROS biocatalysts. Notably, a new nucleophilicattack pathway to eliminate H_2O_2 and produce O_2 is proposed via theoreticalcalculations, and the desorption of the OO* process is identified as therate-determining step of atomic Ru centers. Cellular studies reveal that the newROBCs can efficiently secure the survival, adhesion, spreading, and differentiationof the stem cells in high-ROS-level microenvironments. In vivo rat periodontitistreatments further demonstrate their superior anti-ROS therapeuticeffects. This study provides significant insights into the crucial functions ofRu–N coordinated porphyrin-networks in catalytic ROS-scavenging and offersa new strategy to engineer high-performance antioxidase-like nanobiocatalystsfor stem cell-based therapies and inflammatory diseases.

著录项

来源
《Advanced functional materials》 |2023年第15期|2211778.1-2211778.14|共14页
作者
Jiusi Guo; Zhenyu Xing; Luchang LiuYimin SunHongju ZhouMingru BaiXikui LiuMohsen AdeliChong ChengXianglong Han;
展开▼
作者单位

College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065, China;

State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041, China;

Department of NephrologyWest China HospitalSichuan UniversityChengdu 610041, ChinaDepartment of Organic ChemistryFaculty of ChemistryLorestan UniversityKhorramabad 68137-17133, IranCollege of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065, China, Med-X Center for MaterialsSichuan University Chengdu 610065, ChinaState Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041, China, Med-X Center for MaterialsSichuan University, Chengdu 610065, China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
artificial nanobiocatalysts; inflammatory diseases; nanomedicines; reactive oxygen species; stem cell-based therapies;

Antioxidase-Like Nanobiocatalysts with Ultrafast and Reversible Redox-Centers to Secure Stem Cells and Periodontal Tissues

摘要

著录项

相关主题

期刊订阅