Abstract Background Currently, most studies of ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)‐like protein 4 (Hu antigen D, HuD) focus on nervous system‐related diseases; the role of HuD in the occurrence of skin aging and seborrheic keratosis (SK) has not been reported. Objective To explore the role of HuD in the occurrence of SK and skin aging and its related clinical significance. Methods The expression levels of HuD in the skin and blood of healthy people at different ages, SK lesions, and perilesional skin of SK patients were detected by both immunohistochemistry and Western blotting. The mRNA expression levels of HuD in the skin and blood of healthy peoples at different ages were detected by quantitative real‐time reverse transcription‐polymerase chain reaction. The expression level of HuD was compared with the skin of healthy people, SK lesion, and perilesional skin of SK patients of the same age. Results The immunohistochemistry and Western blotting showed that the expression levels of HuD in SK lesions were higher than those in healthy skin and perilesional skin. The immunohistochemical staining intensity, protein and mRNA expression levels of HuD in the skin and blood of healthy people were correlated with age, which gradually increased with increasing age. Conclusion HuD is highly expressed in SK lesion and aged skin, indicating that a higher HuD expression level is correlated with occurrence of SK and aging skin; however, its mechanism needs to be further studied.
展开▼
