IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2

Goldberg Emily L.; Shchukina Irina; Youm Yun-HeeRyu SeungjinTsusaka TakeshiYoung Kyrlia C.Camell Christina D.Dlugos TamaraArtyomov Maxim N.Dixit Vishwa Deep

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IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2

机译：IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2

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Aging impairs the integrated immunometabolic responses, which have evolved to maintain core body temperature in homeotherms to survive cold stress, infections, and dietary restriction. Adipose tissue inflammation regulates the thermogenic stress response, but how adipose tissue-resident cells instigate thermogenic failure in the aged are unknown. Here, we define alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2s) are lost in aging. Restoration of ILC2 numbers in aged mice to levels seen in adults through IL-33 supplementation failed to rescue old mice from metabolic impairment and increased cold-induced lethality. Transcriptomic analyses revealed intrinsic defects in aged ILC2, and adoptive transfer of adult ILC2s are sufficient to protect old mice against cold. Thus, the functional defects in adipose ILC2s during aging drive thermogenic failure.

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《Cell metabolism》 |2021年第11期|2277-2287|共11页
作者
Goldberg Emily L.; Shchukina Irina; Youm Yun-HeeRyu SeungjinTsusaka TakeshiYoung Kyrlia C.Camell Christina D.Dlugos TamaraArtyomov Maxim N.Dixit Vishwa Deep;
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作者单位

Dept Physiol,Univ Calif San Francisco;

Dept Pathol & Immunol,Washington Univ;

Dept Comparat Med,Yale Sch MedDept Biochem Mol Biol & Mol Biophys,Univ Minnesota;

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正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
REGULATORY T-CELLS; TISSUE; INFLAMMASOME; MACROPHAGES; OBESITY; INSULIN; FAT; INTERLEUKIN-33; ACCUMULATION; LIPOLYSIS;

IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2

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