Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)

Fatemeh Javani Jouni; Jaber Zafari; Mitra AbbasifardMoslem JafarisaniZahra Bagheri-Hosseinabadi

首页> 外文期刊>Cytology and genetics >Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)

【24h】

Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)

机译：Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Lung cancer is one of the most common types of cancer that causes death. In this study, the effects of cisplatin, taurine, and a combination of these two compounds on the A549 cell line were examined. A549 cells were treated with different concentrations of taurine, cisplatin, and the combination of the two compounds. MTT assay, flow cytometry analysis of apoptosis, and flow cytometry analysis of the cell cycle were carried out. The expression of genes was examined by real-time PCR. Cisplatin and taurine reduced the viability of the A549 cell line, but this effect was greater in taurine and cisplatin combination. Cells that were in the G0/G1 stage increased in all treated groups and this inhibition was notable in the combination group. The expression of some genes, such as P53, Bax, caspase 3, caspase 9, and P14, increased. The studies also showed that the cisplatin and taurine combination was moderately synergic with Cl values ranging from X to Y for Fa 0.5. The combination of cisplatin and taurine may be effective in the cancer therapy and it can be a suitable choice for reduction of drug resistance problems and other side effects of cisplatin high dosage, but it is necessary to perform more researches in this field.

著录项

来源
《Cytology and genetics》 |2023年第2期|197-206|共10页
作者
Fatemeh Javani Jouni; Jaber Zafari; Mitra AbbasifardMoslem JafarisaniZahra Bagheri-Hosseinabadi;
展开▼
作者单位

Department ofBiomedical Engineering, Faculty of Health, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran;

Department of Internal Medicine, School of Medicine, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;

Shahroud University of Medicine, Shahroud, IranDepartment of Clinical Biochemistry, Faculty of Medicine and Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
cancer; cell line; cisplatin; taurine; drug-resistance;

Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)

摘要

著录项

相关主题

期刊订阅