Correlations between functional porphyrin positions and accumulation in cancer cells

Tojo Toshifumi; Nishida Koshi; Kondo TakeshiYuasa Makoto

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Correlations between functional porphyrin positions and accumulation in cancer cells

机译：Correlations between functional porphyrin positions and accumulation in cancer cells

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Porphyrin is accumulated in tumours due to its interaction with protein. Cancer therapy with porphyrin as a carrier molecule is attracting attention. Porphyrin displays two functional sites termed beta- and meso-positions. A correlation between the functional position on the porphyrin molecule and the ability to accumulate in cancer cells is observed in the present study. The accumulation of porphyrin derivatives was determined by measuring fluorescence intensity after incubation for 2 and 24 h. The accumulation of cancer cells depended on the position and length of functional groups. Estimated binding constants between porphyrin and bovine serum albumin suggest that the position of functional groups leads to changes in binding affinity and influences the accumulation of porphyrin derivatives in cancer cells.

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2020年第19期|共4页
作者
Tojo Toshifumi; Nishida Koshi; Kondo TakeshiYuasa Makoto;
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作者单位

Tokyo Univ Sci, Fac Sci & Technol, Dept Pure & Appl Chem, 2641 Yamazaki, Noda, Chiba 2788510, Japan;

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正文语种英语
中图分类药学;
关键词
Porphyrin; Tumour accumulation; Fluorescence quenching; pi-pi stacking interaction;

Correlations between functional porphyrin positions and accumulation in cancer cells

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