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首页> 外文期刊>circulation journal >Long-Term Clinical Outcomes of the On-X Mechanical Prosthetic Valve in the Aortic or Mitral Position　― A Single-Center Experience of up to 20 Years’ Follow up ―
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Long-Term Clinical Outcomes of the On-X Mechanical Prosthetic Valve in the Aortic or Mitral Position　― A Single-Center Experience of up to 20 Years’ Follow up ―

机译：Long-Term Clinical Outcomes of the On-X Mechanical Prosthetic Valve in the Aortic or Mitral Position　― A Single-Center Experience of up to 20 Years’ Follow up ―

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Background: This study evaluated the long-term outcomes for up to 20 years after On-X mechanical valve implantation in the left side of the heart. Methods and Results: Between 1999 and 2015, 861 patients (mean age=51.6±10.9 years) who underwent prosthetic valve replacement using the On-X valve in the aortic or mitral position were enrolled (aortic=344, mitral=325, double=192). The mean clinical follow-up duration was 10.5±5.3 (median 10.9) years. Operative mortality occurred in 26 patients (3.0), and linearized late cardiac mortality was 0.9/patient-year without an intergroup difference. Linearized thromboembolism, bleeding, prosthetic valve endocarditis, non-structural valve deterioration (NSVD), and reoperation rates were 0.8/patient-year, 0.6/patient-year, 0.2/patient-year, 0.5/patient-year, and 0.5/patient-year, respectively. Prosthetic valve endocarditis was more frequent after double valve replacement than after aortic or mitral valve replacement (P=0.008 and 0.005, respectively). NSVD and reoperation rates were significantly lower aortic valve replacement than after mitral or double valve replacement (P=0.001 and 0.002, P=0.001 and 0.001, respectively). Valve replacement in the mitral position was the only risk factor for NSVD (hazard ratio 95 confidence interval=5.247 1.608–17.116, P=0.006). Conclusions: On-X valve implantation in the left side heart had favorable clinical outcomes with acceptable early and late mortality and a low incidence of prosthetic valve-related complications. Particularly in the aortic position, the On-X valve had better long-term non-structural durability.

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