Neuroprotective Treatments for Ischemic Stroke: Opportunities for Nanotechnology

Jianglong Kong; Runxuan Chu; Yi Wang

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Neuroprotective Treatments for Ischemic Stroke: Opportunities for Nanotechnology

机译：Neuroprotective Treatments for Ischemic Stroke: Opportunities for Nanotechnology

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Stroke is one of the major causes of death and severe disability worldwide.At present, intravenous thrombolysis to restore blood flow at the ischemicpart of the brain is the main treatment for ischemic stroke. However, even ifpatients are treated in time during the therapeutic window of thrombolyticdrugs, thrombolysis causes a sharp increase in oxygen concentration at theinjury site after ischemia–reperfusion, leading to the outbreak of free radicals,which further aggravates the brain injury. Neuroprotective therapy, which iscombined with thrombolytic therapy, is an important treatment for ischemicstroke and metabolic disorders caused by ischemic brain injury. It can inhibitvarious types of cell necrosis, increase cell viability, delay neuronal death,and promote the recovery of neural functions. This review summarizes novelneuroprotective treatments for stroke, especially nanotechnology-assistedadvanced targeted therapies. Future prospects and challenges are also discussedfor the development of neuroprotective nanomaterials.

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《Advanced functional materials》 |2022年第51期|2209405.1-2209405.23|共23页
作者
Jianglong Kong; Runxuan Chu; Yi Wang;
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作者单位

College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058, P. R. China;

Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203, P. R. China;

College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058, P. R. China,Ningbo Research InstituteZhejiang UniversityNingbo 315100, P. R. China;

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正文语种英语
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关键词
ischemic stroke; neuroprotective; nanoparticles; blood brain barrier;

Neuroprotective Treatments for Ischemic Stroke: Opportunities for Nanotechnology

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