Surface-Acoustic-Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab-On-a-Chip

Matteo Agostini; Francesco Lunardelli; Mariacristina GagliardiAlessio MirandaLeonardo LamannaAntonella Giuliana LuminareFrancesca GambineriMichele LaiMauro PistelloMarco Cecchini

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Surface-Acoustic-Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab-On-a-Chip

机译：Surface-Acoustic-Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab-On-a-Chip

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Measles is one of the most infectious airborne viruses worldwide. With a basic reproduction rate between 12-18, this virus is six times more infectious than the SARS-CoV-2 Alpha variant and similar to the SARS-CoV-2 Omicron variant. Even though a cheap and effective vaccine is available, measles is still common in developing countries. To date, sporadic outbreaks are also reported in developed countries, primarily due to non-vaccinated people. This work presents a point-of-care (POC) biosensing device capable of detecting measles virions (MV) in human saliva. The device is a surface-acoustic-wave (SAW) based lab-on-a-chip (LOC), smaller than a €1-cent coin, in which SAWs are used both for sensing and fluid recirculation. The biosensing detection performance of this system is tested and device sensitivity and selectivity are assessed. The SAW-LOC with MV loaded in healthy, whole human saliva is finally validated. The experimental results also highlight a crucial aspect of the biosensing process: the interactions between probing and target species during incubation with or without fluid mixing. The presented findings are promising for realizing a POC platform for measles diagnosis and may serve as a guideline for designing new microfluidics-based biosensing systems.

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《Advanced functional materials》 |2022年第44期|2201958.1-2201958.10|共10页
作者
Matteo Agostini; Francesco Lunardelli; Mariacristina GagliardiAlessio MirandaLeonardo LamannaAntonella Giuliana LuminareFrancesca GambineriMichele LaiMauro PistelloMarco Cecchini;
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作者单位

INTA S.r.l. Intelligent Acoustics Systems Via Nino Pisano 14, Pisa I-56122, Italy;

NEST Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro, Pisa 56127, Italy;

ARCHA srl, via di Tegulaia, 10/A Ospedaletto, Pisa 56121, ItalyRetrovirus Center Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa 56126, Italy,Virology Unit Pisa University Hospital Pisa 56162, ItalyVirology Unit Pisa University Hospital Pisa 56162, ItalyINTA S.r.l. Intelligent Acoustics Systems Via Nino Pisano 14, Pisa I-56122, Italy,NEST Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro, Pisa 56127, Italy;

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正文语种英语
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acoustic streaming; biosensors; lab-on-a-chip; measles virus; microfluidics; surface acoustic waves; vesicular stomatitis virus;

Surface-Acoustic-Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab-On-a-Chip

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