Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems

Benjamin Madeja; Patrick Wilke; Eduard SchreinerRupert KonradiJohanna ScheckJulien BizzozeroLuc NicoleauElisabeth WagnerMarkus RueckelHelmut CoelfenMatthias Kellermeier

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Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems

机译：Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems

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The design of additives showing strong and selective interactions with certaintarget surfaces is key to crystallization control in applied reactive multicomponentsystems. While suitable chemical motifs can be found through semiempiricaltrial-and-error procedures, bioinspired selection techniques offer amore rationally driven approach and explore a much larger space of possiblecombinations in a single assay. Here, phage display screening is used tocharacterize the surfaces of crystalline gypsum, a mineral of broad relevancefor construction applications. Based on next-generation sequencing of phagesenriched during the screening process, a triplet of amino acids, DYH, is identifiedas the main driver for adsorption on the mineral substrate. Furthermore,oligopeptides containing this motif prove to exert their influence in a strictlyselective manner during the hydration of cement, where the sulfate reaction(initial setting) is strongly retarded while the silicate reaction (final hardening)remains unaffected. In the final step, these desired additive characteristics aresuccessfully translated from the level of peptides to that of scalable syntheticcopolymers. The approach described in this work demonstrates how modernbiotechnological methods can be leveraged for the systematic development ofefficient crystallization additives for materials science.

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《Advanced Materials》 |2023年第20期|2210015.1-2210015.9|共9页
作者
Benjamin Madeja; Patrick Wilke; Eduard SchreinerRupert KonradiJohanna ScheckJulien BizzozeroLuc NicoleauElisabeth WagnerMarkus RueckelHelmut CoelfenMatthias Kellermeier;
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Physical ChemistryUniversity of KonstanzUniversitaetsstr. 10, D-78464 Konstanz, Germany;

Material ScienceBASF SECarl-Bosch-Str. 38, D-67056 Ludwigshafen, Germany;

Molecular ModelingBASF SECarl-Bosch-Str. 38, D-67056 Ludwigshafen, GermanyBiointerfaces and Delivery SystemsBASF SECarl-Bosch-Str. 38, D-67056 Ludwigshafen, GermanyMineralogyBASF Construction Additives GmbHDr.-Albert-Frank-Str. 32, D-83308 Trostberg, Germany;

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正文语种英语
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cementitious materials; construction; crystallization; gypsum; nextgeneration sequencing; phage display; selective hydration control;

Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems

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