• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chem Catalysis >Enantioselective annulation reactions through C(sp~2)-H activation with chiral Cp~xM~(III) catalysts
【24h】

Enantioselective annulation reactions through C(sp~2)-H activation with chiral Cp~xM~(III) catalysts

机译：Enantioselective annulation reactions through C(sp~2)-H activation with chiral Cp~xM~(III) catalysts

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Chiral poly(hetero)cyclic compounds are extensively found in numerous bioactive molecules, natural products, and even functional materials. Synthesis of this class of molecules follows tedious classical synthetic procedures in general. Recent advancement of the transition-metal-catalyzed directed C-H bond activation followed by an intra-/intermolecular cyclization reaction provides an upfront approach to the construction of numerous poly(hetero)cy-clic compounds. However, synthesis of chiral annulated products remains challenging. In general, chiral annulated products are synthesized by a conventional organocatalytic pathway employing suitable chiral ligand systems. Lack of suitable chiral ligands and difficulties in the design and synthesis of appropriate ligands constrain the exploration of the chemistry. Remarkably, recent advances on chiral transition-metal catalysis and chiral ligand-controlled asymmetric C(sp~2)-H bond functionalization chemistry demonstrate a way forward to access chiral annulated products. This review provides an overview of recent advancements in chiral Cp~xM(III)-catalyzed asymmetric annulation reactions, emphasizing the mechanistic understanding of the developed protocols.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号