In Vivo Biocompatibility of Non-derivatized Cellulose Regenerated Using Ionic Liquids

Maree L. Gould; Jithendra T. B. Ratnayake; Niranjan RameshTom J. PowlayOwen J. CurnowMark P. StaigerGeorge J. Dias

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In Vivo Biocompatibility of Non-derivatized Cellulose Regenerated Using Ionic Liquids

机译：In Vivo Biocompatibility of Non-derivatized Cellulose Regenerated Using Ionic Liquids

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The behaviour of regenerated cellulose composites produced from rayon (Cordenka?), dissolved using either ionic liquids or sodium hydroxide (common cellulose solvent) was investigated to determine in vivo biocompatibility. Cellulose-dissolving ionic liquids (1-ethyl-3-methylimidazolium, 1-butyl-3-methylimidazolium, and four triaminocyclopropenium cation salts) and sodium hydroxide were examined in vitro using rat fibroblast-like cells to determine the most cytocompatible ionic liquid. The selected ionic liquid and sodium hydroxide were used to prepare regenerated cellulose constructs. The prepared cellulose constructs and ultra-high-molecular-weight polyethylene controls were implanted subcutaneously into adult male Sprague-Dawley rats. Post-surgery, implants were processed into a resin. Degradation properties were determined, and morphometric analysis was performed on resin sections stained with Haematoxylin Eosin, Toluidine blue and Verhoeff's van Giessen. The implants presented excellent biocompatibility. However, the cellulose implants showed a rapid infiltration of several mature fibroblasts and collagen fibres. A steady increase was observed in the granulation tissue ingrowth between the cellulose fibres by 14 days, increasing a further 35 by 28 days. This study indicates that non-derivatized cellulose regenerated using ionic liquids has the potential to be used as a biocompatible alternative to proteinaceous biomaterials like keratin for biomedical applications.

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《Journal of polymers and the environment》 |2023年第4期|1335-1350|共16页
作者
Maree L. Gould; Jithendra T. B. Ratnayake; Niranjan RameshTom J. PowlayOwen J. CurnowMark P. StaigerGeorge J. Dias;
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作者单位

Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand;

Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin 9054, New Zealand;

Department of Mechanical Engineering, University of Canterbury, Christchurch 8140, New ZealandDepartment of Chemistry, University of Canterbury, Christchurch 8140, New Zealand;

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正文语种英语
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Cellulose; Ionic liquids; Scaffold; Tissue infiltration; Stereology; Degradation;

In Vivo Biocompatibility of Non-derivatized Cellulose Regenerated Using Ionic Liquids

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