Lanthanum nitrate inhibits adipogenesis in 3T3‐L1 preadipocytes with a disorder of mitotic clonal expansion process

Linglu Xu; Qianqian Xiao; Chenping KangXuetao WeiWeidong Hao

首页> 外文期刊>Journal of applied toxicology >Lanthanum nitrate inhibits adipogenesis in 3T3‐L1 preadipocytes with a disorder of mitotic clonal expansion process

【24h】

Lanthanum nitrate inhibits adipogenesis in 3T3‐L1 preadipocytes with a disorder of mitotic clonal expansion process

机译：Lanthanum nitrate inhibits adipogenesis in 3T3‐L1 preadipocytes with a disorder of mitotic clonal expansion process

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract Lanthanum (La) as a rare earth element is widely used in agriculture, industry, and medicine. It has been suggested in several studies that La might influence glycolipid metabolism in vivo. In this study, we used 3T3‐L1 preadipocytes as in vitro cell model to elucidate the effects of La(NO3)3 on adipogenesis and the underlying mechanisms. The results showed that La(NO3)3 could inhibit the adipogenic differentiation of 3T3‐L1 preadipocytes, which showed a decrease in lipid accumulation and the downregulation of specific adipogenic transcription factors. La(NO3)3 exerted its inhibitory effect mainly at the early differentiation stage. Furthermore, La(NO3)3 influenced the S‐phase entry and cell cycle process during the mitotic clonal expansion and regulated the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expressions of the proteins in phosphatidylinositol 3‐kinase (PI3K)/Akt pathway at the early stage of differentiation. Besides, La(NO3)3 upregulated the expressions of wnt10b mRNA and β‐catenin protein and promoted the nucleus translocation of β‐catenin. Additionally, we found that La(NO3)3 could promote the growth of 3T3‐L1 preadipocytes both with and without MDI (3‐isobutyl‐1‐methylxanthine IBMX, dexamethasone Dex, and insulin) stimulation. Collectively, these results indicated that La(NO3)3 could inhibit adipogenesis in 3T3‐L1 preadipocytes and influence cell proliferation.

著录项

来源
《Journal of applied toxicology》 |2023年第4期|402-415|共14页
作者
Linglu Xu; Qianqian Xiao; Chenping KangXuetao WeiWeidong Hao;
展开▼
作者单位

Department of Toxicology, School of Public Health,Peking University, Beijing Key Laboratory of;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类毒物学（毒理学）;
关键词
3T3‐L1 preadipocytes; adipogenesis; lanthanum nitrate; mitotic clonal expansion; wnt/β‐catenin signaling pathway;

Lanthanum nitrate inhibits adipogenesis in 3T3‐L1 preadipocytes with a disorder of mitotic clonal expansion process

摘要

著录项

相关主题

期刊订阅