Tumor metabolism: cancer cells give and take lactate.

Semenza GL

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Tumor metabolism: cancer cells give and take lactate.

机译：Tumor metabolism: cancer cells give and take lactate.

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Tumors contain well-oxygenated (aerobic) and poorly oxygenated (hypoxic) regions, which were thought to utilize glucose for oxidative and glycolytic metabolism, respectively. In this issue of the JCI, Sonveaux et al. show that human cancer cells cultured under hypoxic conditions convert glucose to lactate and extrude it, whereas aerobic cancer cells take up lactate via monocarboxylate transporter 1 (MCT1) and utilize it for oxidative phosphorylation (see the related article beginning on page 3930). When MCT1 is inhibited, aerobic cancer cells take up glucose rather than lactate, and hypoxic cancer cells die due to glucose deprivation. Treatment of tumor-bearing mice with an inhibitor of MCT1 retarded tumor growth. MCT1 expression was detected exclusively in nonhypoxic regions of human cancer biopsy samples, and in combination, these data suggest that MCT1 inhibition holds potential as a novel cancer therapy.

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《The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation》 |2008年第12期|3835-3837|共3页
作者
Semenza GL;
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作者单位

Vascular Program, Institute for Cell Engineering, Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, Maryland, USA. gsemenza@jhmi.edu;

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原文格式 PDF
正文语种英语
中图分类临床医学;
关键词
Animals; Cell Hypoxia; Cell Line; Tumor; Drug Delivery Systems; Gene Expression Regulation; Neoplastic; 动物; 细胞低氧; 药物投与系统; 基因表达调控; 肿瘤; 葡萄糖; 糖原酵解; 乳酸;

Tumor metabolism: cancer cells give and take lactate.

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