Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes

Li Yongting; Wang Xin; Zhu QingqingXu YaqianFu QiuguoWang ThanhLiao ChunyangJiang Guibin

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Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes

机译：Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes

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Organophosphate flame retardants (OPFRs) are found in various environmental matrixes and human samples. Exposure to OPFRs during gestation may interfere with pregnancy, for example, inducing maternal oxidative stress and maternal hypertension during pregnancy, interfering maternal and fetal thyroid hormone secretion and fetal neurodevelopment, and causing fetal metabolic abnormalities. However, the consequences of OPFR exposure on pregnant women, impact on mother-to-child transmission of OPFRs, and harmful effects on fetal and pregnancy outcomes have not been evaluated. This review describes the exposure to OPFRs in pregnant women worldwide, based on metabolites of OPFRs (mOPs) in urine for prenatal exposure and OPFRs in breast milk for postnatal exposure. Predictors of maternal exposure to OPFRs and variability of mOPs in urine have been discussed. Mother-to-child transmission pathways of OPFRs have been scrutinized, considering the levels of OPFRs and their metabolites in amniotic fluid, placenta, deciduae, chorionic villi, and cord blood. The results showed that bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosphate (DPHP) were the two predominant mOPs in urine, with detection frequencies of >90. The estimated daily intake (EDIM) indicates low risk when infants are exposed to OPFRs from breast milk. Furthermore, higher exposure levels of OPFRs in pregnant women may increase the risk of adverse pregnancy outcomes and influence the developmental behavior of infants. This review summarizes the knowledge gaps of OPFRs in pregnant women and highlights the crucial steps for assessing health risks in susceptible populations, such as pregnant women and fetuses.

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《Environmental Science & Technology: ES&T》 |2023年第18期|7109-7128|共20页
作者
Li Yongting; Wang Xin; Zhu QingqingXu YaqianFu QiuguoWang ThanhLiao ChunyangJiang Guibin;
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作者单位

Chinese Acad Sci;

Jianghan Univ;

Orebro Univ;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
organophosphate flame retardants; prenatal exposure; mother-to-child transmission; urine; breast milk; pregnancy outcome; MESSENGER-RNA EXPRESSION; TRIS(1; 3-DICHLORO-2-PROPYL) PHOSPHATE TDCPP; THYROID-HORMONE LEVELS; TRIPHENYL PHOSPHATE; URINARY METABOLITES; BREAST-MILK; DIETARY EXPOSURE; ZEBRAFISH EMBRYOGENESIS; DIPHENYL PHOSPHATE; PRENATAL EXPOSURE;

Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes

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