AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

Gerald T. Ankley; Kelvin Santana‐Rodriguez; Kathleen M. JensenDavid H. MillerDaniel L. Villeneuve

首页> 外文期刊>Environmental toxicology and chemistry / >AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

【24h】

AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

机译：AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Screening and testing of potential endocrine‐disrupting chemicals for ecological effects are examples of risk assessment/regulatory activities that can employ adverse outcome pathways (AOPs) to establish linkages between readily measuredalterations in endocrine function and whole organism– and population‐level responses. Of particular concern are processescontrolled by the hypothalamic–pituitary–gonadal/thyroidal (HPG/T) axes. However, the availability of AOPs suitable to meetthis need is currently limited in terms of species and life‐stage representation relative to the diversity of endpoints influencedby HPG/T function. In our report we describe two novel AOPs that comprise a simple AOP network focused on the effects ofchemicals on sex differentiation during early development in fish. The first AOP (346) documents events starting withinhibition of cytochrome P450 aromatase (CYP19), resulting in decreased availability of 17β‐estradiol during gonad differentiation,which increases the occurrence of testis formation, resulting in a male‐biased sex ratio and consequent populationleveldeclines. The second AOP (376) is initiated by activation of the androgen receptor (AR), also during sexual differentiation,again resulting in a male‐biased sex ratio and population‐level effects. Both AOPs are strongly supported byexisting physiological and toxicological evidence, including numerous fish studies with model CYP19 inhibitors and ARagonists. Accordingly, AOPs 346 and 376 provide a basis for more focused screening and testing of chemicals with thepotential to affect HPG function in fish during early development.

著录项

来源
《Environmental toxicology and chemistry /》 |2023年第4期|747-756|共10页
作者
Gerald T. Ankley; Kelvin Santana‐Rodriguez; Kathleen M. JensenDavid H. MillerDaniel L. Villeneuve;
展开▼
作者单位

Great Lakes Toxicology and Ecology Division, US Environmental Protection Agency, Duluth, Minnesota;

Oak Ridge Institute for Science and Education, Research Participant at Great Lakes Toxicology and Ecology Division, US Environmental Protection Agency,Duluth, Minnesota;

Great Lakes Toxicology and Ecology Division, US Environmental Protection Agency, Ann Arbor, Michigan;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类
关键词
Adverse outcome pathway; Development; Endocrine effects; Fish; Risk assessment;

AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

摘要

著录项

相关主题

期刊订阅