Novel approach toward industrial aromatic nitriles via biocatalysis: From rational enzyme design to sustainable, energy-saving technology platform

Michael Hinzmann; Hilmi Yavuzer; Maike Bittmann

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Novel approach toward industrial aromatic nitriles via biocatalysis: From rational enzyme design to sustainable, energy-saving technology platform

机译：Novel approach toward industrial aromatic nitriles via biocatalysis: From rational enzyme design to sustainable, energy-saving technology platform

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An efficient and broadly applicable synthetic method for the industrial product class of aromatic nitriles is presented, which-in contrast to technical methods such as ammoxidation and substitutions with cyanide-proceeds at energy-saving low temperature and avoids the use of highly toxic cyanide. As catalysts, a set of regioselective enzymes based on the aldoxime dehydratase from Rhodococcus sp. N-771 were identified and, in part, designed by a combined experimental and modeling approach. Due to a tailor-made enlarged active site, the variants M29G and F306A converted meta- and para-substituted substrates with even bulky substituents such as phenyl. In addition, the process runs at high substrate loading (of up to 500 mM as demonstrated for a model process) and shows a promising substrate scope.

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来源
《Chem Catalysis》 |2023年第4期|共15页
作者
Michael Hinzmann; Hilmi Yavuzer; Maike Bittmann;
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作者单位

Chair of Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Universita tsstr. 25, 33615 Bielefeld, Germany;

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正文语种英语
中图分类物理化学（理论化学）、化学物理学;
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Novel approach toward industrial aromatic nitriles via biocatalysis: From rational enzyme design to sustainable, energy-saving technology platform

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