Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement

Isabel Orellano; Alexander Thomas; Aaron HerreraErik BrauerDag WulstenAnsgar PetersenLutz KlokeGeorg N. Duda

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Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement

机译：Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement

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Nutrient supply via a functional vasculature is essential during regenerativeprocesses, tissue growth, and homeostasis. 3D bioprinting offers the opportunityto engineer vascularized constructs by combining cells and biocompatiblematerials in specifically designed fashions. However, the complexity of microvasculardynamic networks can hardly be recapitulated yet, even by sophisticated3D manufacturing. Ideally, the natural organizational competences ofendothelial cells will be harnessed such that engineered vascular networksself-assemble to form complex, controllable microvascular patterns. Here,a bioengineering approach is presented to control microvascular structureformation and to steer cellular self-assembly of endothelial and supporting cellswithin a multi-material stereolithographic 3D bioprinting concept. Bioengineeredvascularized constructs are generated by controlled cell deposition in anenzymatically degradable or a non-degradable material. In vitro, the microvascularstructures are regulated in distribution, network orientation, vessel lengthand branching behavior and developed lumen, signs of vascular stabilizationand an interconnected vascular network including anastomosis. This novelbiofabrication approach demonstrates the capability to control microvascularnetwork formation by using cellular and spatial cues allowing the generationof distinctly yet precisely vascularized constructs. Such novel approach ofcontrolled microvascular formation may play a fundamental role in the developmentof vascularized implants or in vitro screening models.

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《Advanced functional materials》 |2022年第51期|2208325.1-2208325.15|共15页
作者
Isabel Orellano; Alexander Thomas; Aaron HerreraErik BrauerDag WulstenAnsgar PetersenLutz KlokeGeorg N. Duda;
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作者单位

Julius Wolff InstituteBerlin Institute of Health at Charite – Universitaetsmedizin BerlinAugustenburger Platz 1, 13353 Berlin, Germany;

Berlin Institute of Health Center for Regenerative TherapiesBerlin Institute of Health at Charite – Universitaetsmedizin;

Technische Universitaet BerlinDepartment of Medical BiotechnologyGustav-Meyer-Allee 25, 13355 Berlin, Germany;

Cellbricks GmbHMüllerstrasse 178, 13353 Berlin, Germany;

Cellbricks GmbHMüllerstrasse 178, 13353 Berlin, Germany;

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正文语种英语
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bioprinting; controllable microvascular patterning; stereolithography; tissue engineering; vasculature;

Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement

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