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外文期刊>The journal of clinical psychiatry
>Accumulation of Reproductive Safety Data for Second-Generation Atypical Antipsychotics: A Call to Accelerate the Process
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Accumulation of Reproductive Safety Data for Second-Generation Atypical Antipsychotics: A Call to Accelerate the Process
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机译：Accumulation of Reproductive Safety Data for Second-Generation Atypical Antipsychotics: A Call to Accelerate the Process
Second-generation atypical antipsychotics are being increasingly used by reproductive-aged women as primary or adjunctive therapy across a wide range of psychiatric disorders (including bipolar disorder, schizophrenia, unipolar depression, and anxiety disorders).1 Despite the high prevalence of the use of these medications among women of childbearing age, progress in understanding the safe use of atypical antipsychotics across pregnancy, delivery, and breastfeeding has been relatively slow. There is an urgent public health need for more rapid accumulation of systematic reproductive safety data across these medications.In their article, Yakuwa et al2 investigate the risk of major congenital malformations associated with exposure to second-generation antipsychotics (SGAs) in the first trimester. The study cohort consisted of pregnant women who contacted and received a consultation on drug exposure from the Japan Drug Information Institute in Pregnancy, a teratogen information service (TIS) established in 2010. Women who contacted this service from October 2005 to December 2016 were asked to complete a questionnaire at 1 month after their expected delivery date on pregnancy outcomes including date of delivery; gestational age at delivery; birth height, weight, head circumference, and chest circumference; and major malformations in the infant based on maternal report. The exposure group consisted of infants with at least 1 SGA exposure during the first trimester. The comparison group consisted of infants not exposed to SGAs or any other medications known to be teratogenic (such as warfarin, valproic acid, and phenytoin) during pregnancy.
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