Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device　― A 10-Year, Single-Center Historical Cohort Study ―

Hironori Ishiguchi; Akihiko Shimizu; Masahiro IshikuraMasaaki YoshidaKoji ImotoKazuhiko SonoyamaTetsuya KawabataTakashi SugamoriMasaya OgawaTomoyuki UchidaTsukasa NakamuraTakeshi MorimotoYu YasudaKazuaki TanabeYasuhiro YoshigaTakayuki OkamuraShigeki KobayashiMasafumi YanoTsuyoshi Oda

首页> 外文期刊>circulation journal >Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device　― A 10-Year, Single-Center Historical Cohort Study ―

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Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device　― A 10-Year, Single-Center Historical Cohort Study ―

机译：Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device　― A 10-Year, Single-Center Historical Cohort Study ―

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Background: An association between atrial high-rate episode (AHRE) and stroke has been reported, although data for the Asian population are limited. This study aimed to investigate the role of AHRE in ischemic and major bleeding events in patients who underwent a cardiac implantable electronic device (CIED) procedure. Methods and Results: This single-center historical cohort study included 710 patients (age: 78±11 years, 374 women) who underwent a CIED-related procedure between October 2009 and September 2019 at Shimane Prefectural Central Hospital (median follow-up period: 4.5 2.5, 7 years, 3439 person-years). Based on the maximum AHRE burden, patients were divided into: (1) 6 min; (2) ≥6 min to 24-h; and (3) ≥24-h groups. The cumulative incidence of ischemic (ischemic stroke, systemic embolism, and transient ischemic attack) and major bleeding (≥3 Bleeding Academic Research Consortium bleeding criteria) events after the procedure were compared. Uni- and multivariate analyses were performed to identify factors associated with these events. The incidence of both events increased with the rising AHRE burden, being significantly higher in the ≥24-h group than in the 6 min group. Multivariate analysis found age ≥85 years to be the only independent factor associated with both events. Conclusions: Longer AHRE duration is associated with a high number of major bleeding and ischemic events. Monitoring these bleeding risks is mandatory when clinicians are considering anticoagulation therapy for such patients.

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来源
《circulation journal》 |2021年第8期|1329-1337|共9页
作者
Hironori Ishiguchi; Akihiko Shimizu; Masahiro IshikuraMasaaki YoshidaKoji ImotoKazuhiko SonoyamaTetsuya KawabataTakashi SugamoriMasaya OgawaTomoyuki UchidaTsukasa NakamuraTakeshi MorimotoYu YasudaKazuaki TanabeYasuhiro YoshigaTakayuki OkamuraShigeki KobayashiMasafumi YanoTsuyoshi Oda;
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作者单位

Division of Cardiology, Shimane Prefectural Central Hospital;

Department of Cardiology, Ube-Kohsan Central Hospital;

Department of Cardiology, Oda City HospitalDepartment of Internal Medicine, Oki HospitalDepartment of Cardiology, National Hospital Organisation Hamada Medical CenterDepartment of Medical Education, Shimane Prefectural Central HospitalDepartment of Clinical Epidemiology Center for Clinical Research and Education, Hyogo College of MedicineDivision of Cardiology, Faculty of Medicine, Shimane UniversityDivision of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine;

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Atrial high-rate episode; Cardiac implantable electronic device; Ischemic stroke; Major bleeding;

Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device ― A 10-Year, Single-Center Historical Cohort Study ―

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Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device　― A 10-Year, Single-Center Historical Cohort Study ―