Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women

Biegon Anat; Alia-Klein Nelly; Alexoff David L.Fowler Joanna S.Kim Sung WonLogan JeanPareto DeborahPreston-Campbell RebeccaWang Gene-JackHildebrandt Tom

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Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women

机译：Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women

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Gonadal hormones are linked to mechanisms that govern appetitive behavior and its suppression. Estrogens are synthesized from androgens by the enzyme aromatase, highly expressed in the ovaries of reproductive-aged women and in the brains of men and women of all ages. We measured aromatase availability in the amygdala using positron emission tomography (PET) with the aromatase inhibitor C-11vorozole in a sample of 43 adult, normalweight, overweight, or obese men and women. A subsample of 27 also completed personality measures to examine the relationship between aromatase and personality traits related to self-regulation and inhibitory control. Results indicated that aromatase availability in the amygdala was negatively associated with body mass index (BMI) (in kilograms per square meter) and positively correlated with scores of the personality trait constraint independent of sex or age. Individual variations in the brain's capacity to synthesize estrogen may influence the risk of obesity and self-control in men and women.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2020年第37期|22962-22966|共5页
作者
Biegon Anat; Alia-Klein Nelly; Alexoff David L.Fowler Joanna S.Kim Sung WonLogan JeanPareto DeborahPreston-Campbell RebeccaWang Gene-JackHildebrandt Tom;
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作者单位

Dept Radiol & Neurol,SUNY Stony Brook;

Dept Psychiat,Icahn Sch Med Mt Sinai;

Fiveeleven PharmaDept Chem,Brookhaven Natl LabLab Neuroimaging,NIAAADept Radiol,NYUMagnet Resonance Unit,Vall dHebron Univ HospMissouri Inst Mental Hlth;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
aromatase; obesity; estrogen; amygdala; PET imaging; BODY-WEIGHT; SEX-DIFFERENCES; EXTRAGONADAL SYNTHESIS; ANDROGEN RECEPTOR; FOOD STIMULI; HIGH-CALORIE; MEAL SIZE; IN-VIVO; AROMATASE; AMYGDALA;

Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women

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