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首页> 外文期刊>The journal of asthma >Exercise induced bronchodilation: a phenomenon more common, greater magnitude and more prolonged in older adults than in adolescents
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Exercise induced bronchodilation: a phenomenon more common, greater magnitude and more prolonged in older adults than in adolescents

机译：Exercise induced bronchodilation: a phenomenon more common, greater magnitude and more prolonged in older adults than in adolescents

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Objective There are few studies in clinically healthy subjects describing and quantifying exercise-induced bronchodilation (EIBd). This study aimed to describe and compare the magnitude and time course changes in post-exercise forced expired volume at the first second (FEV1) in healthy adolescents, younger adults, and older adults. Methods Adolescent (n = 73, aged 10-17 years), younger adult (n = 35, aged 18-25 years), and older adult (n = 25, aged 35-66 years) subjects with normal spirometry z-scores completed a maximal cardiopulmonary exercise test using the standardized exponential exercise test protocol on a cycle ergometer performed at stable temperature and humidity. Spirometry was performed pre-exercise and at 1-, 3-, 5-, and 10-minutes post-exercise to determine the percentage change in FEV1 compared to baseline. EIBd was defined as a >= 5 increase in post-exercise FEV1. Results Increases in FEV1 at one-minute post-exercise were observed in the adolescents (1.3) and young adults (6.0) with FEV1 returning to baseline after ten minutes. Compared to the adolescents, the older adults showed significantly greater and sustained increases in FEV1 at 1-, 3-, 5-, and 10-minutes post-exercise (6.4, 4.6, 4.7, and 3.8, p < 0.05). At 1-minute post exercise a significantly greater proportion of younger adults (54, p < 0.01) and older adults (64, p < 0.01) demonstrated EIBd compared to the adolescent group (15). Conclusion Healthy older adults had a higher prevalence, greater magnitude and more prolonged EIBd compared to healthy adolescent and young adult subjects.

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