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首页> 外文期刊>Science of advanced materials >Polyethylene Glycol Diacrylate (PEGMA) and Polyvinylpyrrolidone (PVP) Delivering Solifenacine as Super Smooth Coating of Ureteral Stent to Relieve Stent Syndrome: In Vitro and In Vivo Study
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Polyethylene Glycol Diacrylate (PEGMA) and Polyvinylpyrrolidone (PVP) Delivering Solifenacine as Super Smooth Coating of Ureteral Stent to Relieve Stent Syndrome: In Vitro and In Vivo Study

机译:Polyethylene Glycol Diacrylate (PEGMA) and Polyvinylpyrrolidone (PVP) Delivering Solifenacine as Super Smooth Coating of Ureteral Stent to Relieve Stent Syndrome: In Vitro and In Vivo Study

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摘要

Urinary calculus is a very common disease in urology. Ureteral stent is popularly used in patients after surgeries to protect the ureter. Indwelling ureteral stent inevitably causes stent syndrome for the reason of foreign body stimulation and rough stent surface. Clinicaly, oral administration of solifenacine is a solution to relieve the symptoms, however it is with several complications. In our study, ureteral stent was coated with bioac-tive solifenacine in polyethylene glycol diacrylate (PEGMA) and polyvinylpyrrolidone (PVP) to realize super smooth surface and controlled release of solifenacine. Scanning electron microscopy (SEM) and friction test of solifenacin-loaded super-smooth stent (SSSS) revealed its smooth surface. Fourier transform infrared spec-troscopy and controlled release test showed its solifenacin delivering and controlled releasing. The polymerase chain reaction (PCR) showed inhibited α-smooth mucle actin expression in SSSS treated smooth muscle cells. The SSSS was applied in male New Zealand rabbits and revealed the effect of inhibiting the abnormal contraction of bladders. The Histology of SSSS treated bladder revealed a diastolic muscle layer of bladder. The SSSS after implantation showed smoother surface and less calcium deposition. In conclusion, it's demonstrated that the SSSS has the efficacy of relieving stent syndrome and potential for clinical translation and application.

著录项

  • 来源
    《Science of advanced materials》 |2023年第4期|509-519|共11页
  • 作者单位

    School of Materials Science and Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China, The Department of Urology, Affiliated Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, China;

    Jiangsu Biosurf Biotech Co., Ltd., Building 26, NO.1 Jintian Road, Suzhou, 215000, PR China;

    School of Materials Science and Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China, Jiangsu Biosurf Biotech Co., Ltd., Building 26, NO.1 Jintian Road, Suzhou, 215000, PR ChinaSchool of Materials Science and Engineering, Shanghai University of Engineering Science, Shanghai, 201620, ChinaGuangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545006, ChinaWake Forest Institute of Regenerative Medicine, Winston Salem, North Carolina, 27109, USAApplied Medical Science Department, Community College, King Saud University, P.O. Box 11433, Riyadh, Saudi ArabiaDepartment of Medical Science, Lab of Microbiology and Genetics, Jeonbuk National University, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of KoreaMount Carmel Health System, Columbus, 43123, OH, USAThe Department of Urology, Affiliated Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, China;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 工程材料学;
  • 关键词

    Ureteral Stent Syndrome; Solifenacin; Polyethylene Glycol Diacrylate; Polyvinylpyrrolidone;

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