Efficient enzymatic synthesis of L‐ascorbyl palmitate using Candida antarctica lipase B‐embedded metal‐organic framework

Xiao‐Jian Zhang; Feng‐Yu Qi; Jia‐Mei QiFei YangJiang‐Wei ShenXue CaiZhi‐Qiang LiuYu‐Guo Zheng

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Efficient enzymatic synthesis of L‐ascorbyl palmitate using Candida antarctica lipase B‐embedded metal‐organic framework

机译：Efficient enzymatic synthesis of L‐ascorbyl palmitate using Candida antarctica lipase B‐embedded metal‐organic framework

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Abstract The Candida antarctica lipase B (CALB) was embedded in the metal‐organic framework, zeolitic imidazolate framework‐8 (ZIF‐8), and applied in the enzymatic synthesis of L‐ascorbic acid palmitate (ASP) for the first time. The obtained CALB@ZIF‐8 achieved the enzyme loading of 80 mg g−1 with 11.3 U g−1 (dry weight) unit activity, 59.8 activity recovery, and 92.7 immobilization yield. Under the optimal condition, ASP was synthesized with over 75.9 conversion of L‐ascorbic acid in a 10‐batch reaction. Continuous synthesis of ASP was subsequently performed in a packed bed bioreactor with an outstanding average space–time yield of 58.1 g L−1 h−1, which was higher than ever reported continuous ASP biosynthesis reactions.

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《Biotechnology Progress》 |2022年第1期|n/a-n/a|共11页
作者
Xiao‐Jian Zhang; Feng‐Yu Qi; Jia‐Mei QiFei YangJiang‐Wei ShenXue CaiZhi‐Qiang LiuYu‐Guo Zheng;
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Zhejiang University of Technology;

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原文格式 PDF
正文语种英语
中图分类生物科学;
关键词
continuous production; immobilized CALB; L‐ascorbyl palmitate; metal‐organic frameworks; packed bed bioreactor;

Efficient enzymatic synthesis of L‐ascorbyl palmitate using Candida antarctica lipase B‐embedded metal‐organic framework

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