Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine

Uwamino Yoshifumi; Kurafuji Toshinobu; Takato KumikoSakai AkikoTanabe AkikoNoguchi MasayoYatabe YokoArai TomokoOhno AkemiTomita YukariShibata AyakoYokota HiromitsuYamasawa WakakoNamkoong HoSato YasunoriHasegawa NaokiWakui MasatoshiMurata MitsuruKeio Donner Project Team

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Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine

机译：Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine

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Background: The antibody titer is known to wane within months after receiving two doses of the Pfizer-BioNTech BNT162b2 mRNA SARS-CoV-2 vaccine. However, knowledge of the cellular immune response dynamics following vaccination is limited. This study to aimed to determine antibody and cellular immune responses following vaccination, and the incidence and determinants of breakthrough infection. Methods: This prospective cohort study a 6-month follow-up period was conducted among Japanese healthcare workers. All participants received two doses of BNT162b2 vaccine. Anti-SARS-CoV-2 antibody titers and T-cell immune responses were measured in serum samples collected at several timepoints before and after vaccination. Results: A total of 608 participants were included in the analysis. Antibody titers were elevated 3 weeks after vaccination and waned over the remainder of the study period. T-cell immune responses showed similar dynamics. Six participants without predisposing medical conditions seroconverted from negative to positive on the IgG assay for nucleocapsid proteins, indicating breakthrough SARS-CoV-2 infection. Five of the six breakthrough infections were asymptomatic. Conclusions: Both humoral and cellular immunity waned within 6 months after BNT162b2 vaccination. The incidence of asymptomatic breakthrough infection within 6 months after vaccination was approximately one percent. (C) 2022 Elsevier Ltd. All rights reserved.

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《Vaccine》 |2022年第32期|4538-4543|共6页
作者
Uwamino Yoshifumi; Kurafuji Toshinobu; Takato KumikoSakai AkikoTanabe AkikoNoguchi MasayoYatabe YokoArai TomokoOhno AkemiTomita YukariShibata AyakoYokota HiromitsuYamasawa WakakoNamkoong HoSato YasunoriHasegawa NaokiWakui MasatoshiMurata MitsuruKeio Donner Project Team;
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Keio Univ;

Keio Univ Hosp;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
COVID-19; SARS-CoV-2; BNT162b2 vaccine; mRNA vaccines; Immune response; Breakthrough infections; Healthcare workers;

Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine

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