Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Sturny Mikael; Anguenot Lea; Costa-Fraga Fabiana P.Bragina Maiia E.Lima Augusto Martinsda Silva Rafaela F.Fraga-Silva Rodrigo A.Stergiopulos Nikolaos

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Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

机译：Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

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Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, controlling vascular function and reducing fibrosis in multiple pathological conditions. Recently, initial studies have shown that Apelin, acting through the APJ receptor, also modulates penile erection, however, the role of this system on penile structure and intracorporal collagen remodeling has not been investigated yet.

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《The journal of sexual medicine》 |2021年第5期|875-888|共14页
作者
Sturny Mikael; Anguenot Lea; Costa-Fraga Fabiana P.Bragina Maiia E.Lima Augusto Martinsda Silva Rafaela F.Fraga-Silva Rodrigo A.Stergiopulos Nikolaos;
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Ecole Polytech Fed Lausanne, Inst Bioengn, EPFL STI IBI LHTC MED 32526 Stn 9, CH-1015 Lausanne;

Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG, Brazil;

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正文语种英语
中图分类性卫生;
关键词
Erectile Dysfunction; Hypercholesterolemia; Apelin; APJ Receptor; Fibrosis; Matrix Metalloproteinase;

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

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