Cardiometabolic Profiles in Women with a History of Hypertensive and Normotensive Fetal Growth Restriction

Rianne C. Bijl; Jér?me M.J. Cornette; Blanka VasakArie FranxA. Titia LelyMichiel L. BotsBas B. van RijnMaria P.H. Koster

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Cardiometabolic Profiles in Women with a History of Hypertensive and Normotensive Fetal Growth Restriction

机译：Cardiometabolic Profiles in Women with a History of Hypertensive and Normotensive Fetal Growth Restriction

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Background: The majority of evidence on associations between pregnancy complications and future maternal disease focuses on hypertensive (Ht) complications. We hypothesize that impaired cardiometabolic health after pregnancies complicated by severe fetal growth restriction (FGR) is independent of the co-occurrence of hypertension.Materials and Methods: In a prospective cohort of women with a pregnancy complicated by early FGR (delivery Results: Median time from delivery to assessment was 4 months in both the Ht (N = 115) and normotensive (Nt) (N = 42) FGR groups. Compared with the reference group (N = 380), in both FGR groups lipid profile and glucose homeostasis at assessment were unfavorable. Women with Ht-FGR had the least favorable cardiometabolic profile, with higher prevalence ratios (PRs) for diastolic blood pressure >85 mmHg (PR 4.0, 95 confidence interval CI 2.1–6.7), fasting glucose levels >5.6 mmol/L (PR 2.9, 95 CI 1.4–5.6), and total cholesterol levels >6.21 mmol/L (PR 4.5, 95 CI 1.9–8.8), compared with the reference group. Women with Nt-FGR more often had a BMI >30 kg/m2 (PR 2.5, 95 CI 1.2–4.7) and high-density lipoprotein-cholesterol levels Conclusions: Women with a history of FGR showed unfavorable short-term cardiometabolic profiles in comparison with a reference group, independent of the co-occurrence of hypertension. Therefore, women with a history of FGR may benefit from cardiovascular risk factor assessment and subsequent risk reduction strategies.

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《Journal of women’s health》 |2022年第1期|63-70|共8页
作者
Rianne C. Bijl; Jér?me M.J. Cornette; Blanka VasakArie FranxA. Titia LelyMichiel L. BotsBas B. van RijnMaria P.H. Koster;
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作者单位

Department of Obstetrics and Gynecology, Erasmus University Medical Center;

Department of Obstetrics and Gynecology, University Medical Center Utrecht;

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht;

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正文语种英语
中图分类妇幼卫生;
关键词
cardiometabolic risk factors; intrauterine fetal growth restriction; pregnancy; pre-eclampsia; prevention; cardiovascular disease;

Cardiometabolic Profiles in Women with a History of Hypertensive and Normotensive Fetal Growth Restriction

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