Targeting bacterial transferrin and lactoferrin receptors for vaccines

Schryvers A.B.

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Targeting bacterial transferrin and lactoferrin receptors for vaccines

机译：Targeting bacterial transferrin and lactoferrin receptors for vaccines

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© 2022 The AuthorA substantial disease burden in vertebrates is due to Gram-negative bacteria that exclusively inhabit the upper respiratory or genitourinary tracts of their hosts and rely on directly acquiring iron from the host iron-binding glycoproteins through surface receptor proteins. The receptors enable these bacteria to proliferate independently from their neighbors on the mucosal surface and during invasive infection of the host. The diversity in these receptors evolved over millions of years of evolution, which thus bodes well for long-lasting vaccine coverage. Experiments in food production animals provide proof of concept for the use of engineered antigens derived from the receptor proteins to prevent colonization and invasive infection in the natural host, strongly supporting development of these vaccines for use in humans.

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《Trends in Microbiology》 |2022年第9期|820-830|共11页
作者
Schryvers A.B.;
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Department of Microbiology Immunology and Infectious Diseases Snyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
iron; lactoferrin; receptor; transferrin; transport; vaccine;

Targeting bacterial transferrin and lactoferrin receptors for vaccines

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