In this issue of Chem Catalysis, Huang and co-workers report a Pd-cata-lyzed stereodivergent 4 + 2 annulation of alkylidene pyrazolones with vinyl benzoxazinanones via ligand regulation, synthesizing an array of 6.5-spiropyrazolones bearing three contiguous stereocenters with high yields and stereoselectivities. The origin of this stereodivergent annulation process was revealed by DFT calculation.
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