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首页> 外文期刊>febs open bio >A Hill type equation can predict target gene expression driven by p53 pulsing
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A Hill type equation can predict target gene expression driven by p53 pulsing

机译：A Hill type equation can predict target gene expression driven by p53 pulsing

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摘要

Many factors determine target gene expression dynamics under p53 pulsing. In this study, I sought to determine the mechanism by which duration, frequency, binding affinity and maximal transcription rate affect the expression dynamics of target genes. Using an analytical method to solve a simple model, I found that the fold change of target gene expression increases relative to the number of p53 pulses, and the optimal frequency, 0.18 hsup−1/sup, from two real p53 pulses drives the maximal fold change with a decay rate of 0.18 hsup−1/sup. Moreover, p53 pulses may also lead to a higher fold change than sustained p53. Finally, I discovered that a Hill-type equation, including these effect factors, can characterise target gene expression. The average error between the theoretical predictions and experiments was 23. Collectively, this equation advances the understanding of transcription factor dynamics, where duration and frequency play a significant role in the fine regulation of target gene expression with higher binding affinity.

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