Interactive toxicity of copper and cadmium in regenerating and adult planarians

Majid Sanah; Van Belleghem Frank; Ploem Jan-PieterWouters AnneliesBlust RonnySmeets Karen

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Interactive toxicity of copper and cadmium in regenerating and adult planarians

机译：Interactive toxicity of copper and cadmium in regenerating and adult planarians

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In a polluted environment, metals are present as complex mixtures. As a result, organisms are exposed to different metals at the same time, which affects both metal-specific as well as overall toxicity. Detailed information about the molecular mechanisms underlying the adverse effects of combined exposures remains limited in terms of different life stages. In this study, the freshwater planarian Schmidtea mediterranea was used to investigate developmental and physiological responses associated with a combined exposure to Cu and Cd. In addition, the cellular and molecular mechanisms underlying the provoked adverse effects were studied in different exposure scenarios. Mixed exposure resulted in a decline in survival, diverse non-lethal morphological changes, neuroregenerative impairments, altered behaviour and a limited repair capacity. Underlying to these effects, the cellular redox state was altered in all exposure conditions. In adult animals, this led to DNA damage and corresponding transcriptional changes in cell cycle and DNA repair genes. In regenerating animals, changes in hydrogen peroxide and glutathione contents led to regenerative defects. Overall, our results demonstrate that (1) developing organisms are more susceptible to metal exposures, and (2) the toxicity of an individual metal increases significantly in a mixed exposure scenario. These aspects have to be included in current risk assessment strategies.

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《Chemosphere》 |2022年第6期|133819.1-133819.15|共15页
作者
Majid Sanah; Van Belleghem Frank; Ploem Jan-PieterWouters AnneliesBlust RonnySmeets Karen;
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作者单位

Hasselt Univ, Ctr Environm Sci CMK, Lab Toxicol, B-3590 Diepenbeek, Belgium|Univ Antwerp, Dept Biol, Syst Physiol & Ecotoxicol Res Sphere, Groenenborgerlaan, B-2020 Antwerp, Belgium;

Hasselt Univ, Ctr Environm Sci CMK, Lab Toxicol, B-3590 Diepenbeek, Belgium|Open Univ Netherlands, Fac Sci, Dept Environm Sci, NL-6419 AT Heerlen, Netherlands;

Hasselt Univ, Ctr Environm Sci CMK, Lab Toxicol, B-3590 Diepenbeek, BelgiumUniv Antwerp, Dept Biol, Syst Physiol & Ecotoxicol Res Sphere, Groenenborgerlaan, B-2020 Antwerp, Belgium;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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Toxicity; Metals; Planarians; Developmental effects; Neurotoxicity;

Interactive toxicity of copper and cadmium in regenerating and adult planarians

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