Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by amp;iamp;in Silicoamp;/iamp;, amp;iamp;in Vitroamp;/iamp; and amp;iamp;in Vivoamp;/iamp; Methods

Baktygul Ernazarova; Taitokur Zhusubaliev; Zarylkan Asilbek kyzyAida BakirovaGulsara ZhusupbaevaOrozby AkparalievaZhypargul AbdullaevaNasibakhon RazykovaAsilkan DzhumanazarovaGalina ApryshkoAlina Orozmatova

首页> 外文期刊>Journal of Agricultural Chemistry and Environment >Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by amp;iamp;in Silicoamp;/iamp;, amp;iamp;in Vitroamp;/iamp; and amp;iamp;in Vivoamp;/iamp; Methods

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Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by amp;iamp;in Silicoamp;/iamp;, amp;iamp;in Vitroamp;/iamp; and amp;iamp;in Vivoamp;/iamp; Methods

机译：Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by amp;iamp;in Silicoamp;/iamp;, amp;iamp;in Vitroamp;/iamp; and amp;iamp;in Vivoamp;/iamp; Methods

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Computer analysis of N-( β -D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-( β -D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.

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来源
《Journal of Agricultural Chemistry and Environment》 |2022年第1期|15-23|共9页
作者
Baktygul Ernazarova; Taitokur Zhusubaliev; Zarylkan Asilbek kyzyAida BakirovaGulsara ZhusupbaevaOrozby AkparalievaZhypargul AbdullaevaNasibakhon RazykovaAsilkan DzhumanazarovaGalina ApryshkoAlina Orozmatova;
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作者单位

Department of Pharmacy and Medical-Biological Disciplines, Zhalal-Abad State University;

Zhalal-Abad Scientific Center, South Department Academy of Sciences;

Science and Research Department, Osh State UniversityInstitute of Chemistry and Phytotechnology, National Academy of SciencesNational Medical Research Center of Oncology Named after N.N. Blokhin;

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正文语种英语
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Biological Activity; Synthesis; Urea; Carbohydrate; Compounds; Hyperurcemia; Ototoxicity; Testing; Toxicity; Anti Tuberculosis; Antitumor;

Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by amp;iamp;in Silicoamp;/iamp;, amp;iamp;in Vitroamp;/iamp; and amp;iamp;in Vivoamp;/iamp; Methods

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