Plasma PFOA and PFOS Levels,DNA Methylation,and Blood Lipid Levels:A Pilot Study

Xu Cheng; Yue Wei; Zefang Zhang

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Plasma PFOA and PFOS Levels,DNA Methylation,and Blood Lipid Levels:A Pilot Study

机译：Plasma PFOA and PFOS Levels,DNA Methylation,and Blood Lipid Levels:A Pilot Study

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Exposure to perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS)is associated with blood lipids in adults,but the underlying mechanisms remain unclear.This pilot study aimed to investigate the associations between PFOA or PFOS and epigenome-wide DNA methylation and assess the mediating effect of DNA methylation on the PFOA/PFOS-blood lipid association.We measured plasma PFOA/PFOS and leukocyte DNA methylation in 98 patients enrolled from the hospital between October 2018 and August 2019.The median plasma PFOA/PFOS levels were 0.85 and 2.29 ng/mL.Plasma PFOA and PFOS levels were significantly associated with elevated total cholesterol(TC)and low-density lipoprotein cholesterol(LDL)levels.There were 63/87 CpG positions and 8/11 differentially methylated regions(DMRs)associated with plasma PFOA/PFOS levels,respectively.In addition,5 CpG positions(annotated to AFF3,CREBS,NRG2,USF2,and intergenic region)and one DMR annotated to IRF6 may mediate the association between plasma PFOA/PFOS and LDL levels(mediated proportion from 7.29 to 46.77);two CpG positions may mediate the association between plasma PFOA/PFOS and TC levels(annotated to CREBS and USF2,mediated proportion is around 30).The data suggest that PFOA/PFOS exposure alters DNA methylation.More importantly,the association of PFOA/PFOS with lipid indicators was partly mediated by DNA methylation changes in lipid metabolism-related genes.

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《Environmental Science & Technology: ES&T》 |2022年第23期|17039-17051|共13页
作者
Xu Cheng; Yue Wei; Zefang Zhang;
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作者单位

Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

Department of Occupational;

Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
PFOA; PFOS; DNA methylation; blood lipid; IRF6; USF2;

Plasma PFOA and PFOS Levels,DNA Methylation,and Blood Lipid Levels:A Pilot Study

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