Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

Valencia-Hernandez A.M.; Zillinger T.; Ge Z.Tan P.S.Cozijnsen A.I. McFadden G.Lahoud M.H.Caminschi I.Barchet W.Heath W.R.Fernandez-Ruiz D.

首页> 外文期刊>Vaccine >Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

【24h】

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

机译：Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

© 2022 Elsevier LtdTissue resident memory T cells (TRM cells) can provide effective tissue surveillance and can respond rapidly to infection. Vaccination strategies aimed at generating TRM cells have shown promise against a range of pathogens. We have previously shown that the choice of adjuvant critically influences CD8+ TRM cell formation in the liver. However, the range of adjuvants tested was limited. Here, we assessed the ability of a broad range of adjuvants stimulating membrane (TLR4), endosomal (TLR3, TLR7 and TLR9) and cytosolic (cGAS, RIG-I) pathogen recognition receptors for their capacity to induce CD8+ TRM formation in a subunit vaccination model. We show that CpG oligodeoxynucleotides (ODN) remain the most efficient inducers of liver TRM cells among all adjuvants tested. Moreover, their combination with the cationic liposome DOTAP further enhances the potency, particularly of the class B ODN CpG 1668 and the human TLR9 ligand CpG 2006 (CpG 7909). This study informs the design of efficient liver TRM-based vaccines for their potential translation.

著录项

来源
《Vaccine》 |2023年第5期|1094-1107|共14页
作者
Valencia-Hernandez A.M.; Zillinger T.; Ge Z.Tan P.S.Cozijnsen A.I. McFadden G.Lahoud M.H.Caminschi I.Barchet W.Heath W.R.Fernandez-Ruiz D.;
展开▼
作者单位

Dept. of Microbiology and Immunology Peter Doherty Institute The University of Melbourne;

Institute of Clinical Chemistry and Clinical Pharmacology University Hospital of Bonn;

Infection and Immunity Program Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash UniversitySchool of Biosciences University of Melbourne;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
Adjuvants; Liver immunology; Pattern recognition receptors; T cell memory; Tissue-resident memory T cells; Toll-like receptors; type I dendritic cells; Vaccination;

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

摘要

著录项

相关主题

期刊订阅