Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics

Shidong Wang; Chenglong Chen; Juan WangChen-Bo-Wen LiJinling ZhouYi-Xuan LiuYu-Qi JiangLifeng ZhuChao LiWen GongWei GuoXiaodong TangFang-Zhou YaoKe Wang

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Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics

机译：Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics

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Osteosarcoma (OS) is a lethal malignancy of the bone, jeopardizing the life of an enormous population worldwide. There are grand ongoing challenges to improve overall patient survival. Herein, a synergetic chemo-piezodynamic therapy by defect-engineered lead-free piezoelectric (K,Na)NbO_3 (KNN) is reported, which can generate reactive oxygen species (ROS) to effectively circumvent OS. Significant anti-tumor effects in human OS cells, and xenograft OS models are observed that almost stop the growth of the tumors after treatment with KNN because of oxygen vacancies-driven free radical catalysis (namely, the chemodynamic therapy), and those effects are enhanced after introducing ultrasonic vibration enabled by the ultrasound-triggered piezocatalysis (piezodynamic therapy). Moreover, it is found that KNN induces apoptosis and autophagy of OS cells and shows good histocompatibility on evaluation in mouse models, which has no killing effect on normal cells and no toxic effects on organs in vivo. Both in vitro cellular level evaluation and in vivo OS xenograft assessment have demonstrated that injectable KNN nanocrystals induce cytotoxicity and tumor eradication by the synergy of chemo-piezocatalytic effects. This study opens an avenue for customized design of high-tech nanocatalysts by integrating synergetic catalytic effects for therapeutic applications in tumor healthcare.

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来源
《Advanced functional materials》 |2022年第44期|2208128.1-2208128.11|共11页
作者
Shidong Wang; Chenglong Chen; Juan WangChen-Bo-Wen LiJinling ZhouYi-Xuan LiuYu-Qi JiangLifeng ZhuChao LiWen GongWei GuoXiaodong TangFang-Zhou YaoKe Wang;
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Musculoskeletal Tumor Center Peking University People’s Hospital Beijing 100044, P. R. China;

Beijing Jishuitan Hospital Beijing 100035, P. R. China;

State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084, P. R. ChinaSchool of Materials Science and Engineering University of New South Wales Kensington, NSW 2052, AustraliaSchool of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083, P. R. ChinaInstrumental Analysis Center Xi’an Jiaotong University Xi’an 710049, P. R. ChinaWuzhen Laboratory Jiaxing 314500, P. R. China;

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正文语种英语
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chemodynamic therapies; (K; Na)NbO3; lead-free piezoelectrics; osteosarcoma; piezodynamic therapies;

Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics

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