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Reusable Dual-Photopolymerized Holographic Glucose Sensors

机译：Reusable Dual-Photopolymerized Holographic Glucose Sensors

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摘要

Diabetes is well established as a widespread, incurable, and fatal diseasewith glucose monitoring and tight glycaemic control vital for effective illnessprevention and management. Hydrogel-based holographic sensorsserve as a low-cost and label-free colorimetric sensing platform, directlyidentifiable by the naked eye and spectroscopy for quantitative monitoring.Herein, a cost-effective and reusable holographic glucose sensor is developedvia single pulse UV-induced dual-photopolymerization of boronic acidfunctionalized hydrogels for point-of-care (POC) diagnosis. Computationalmodeling of holographic sensors response is conducted following Braggslaw alongside the study of fabrication parameter optimization and sensorswelling dynamics. Fabrication conditions, responsive and interferencehydrogel compositions of holographic sensors are investigated to improveresponse time, sensitivity in urine (13.03 nm mmol~(?1) L~(?1)), limit of detection(0.06 mmol L~(?1)), and reusability. Photolithographic patterning of hydrogelbasedholographic sensors permits the inscription of additional informationinto the sensors for qualitative measurement. Selectivity, reversibility, andcontinuous monitoring of urine samples are conducted over a physiologicalglucose concentration range (0.0–9.4 mmol L~(?1)) to demonstrate the viabilityfor diabetic risk identification. The simple incorporation of glucose sensorsin a reusable urinary analysis prototype is validated in human urine,showing potential for POC to reduce patient dependency on invasive diabeticmonitoring procedures.

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