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首页> 外文期刊>Journal of applied toxicology >Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies
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Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

机译：Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

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Curcumin, one of the three principal curcuminoids found within turmeric rhizomes, has long been associated with numerous physiologically beneficial effects; however, its efficacy is limited by its inherently low bioavailability. Several novel formulations of curcumin extracts have been prepared in recent years to increase the systemic availability of curcumin; Longvida?, a solid lipid curcumin particle preparation, is one such formulation that has shown enhanced bioavailability compared with standard curcuminoid extracts. As part of a safety assessment of Longvida? for use as a food ingredient, a bacterial reverse mutation test (OECD TG 471) and mammalian cell erythrocyte micronucleus test (OECD TG 474) were conducted to assess its genotoxic potential. In the bacterial reverse mutation test, Longvida? did not induce base-pair or frame-shift mutations at the histidine locus in the genome of Salmonella typhimurium strains TA98, TA100, TA102, TA1535, and TA1537, in the presence or absence of exogenous metabolic activation. Additionally, two gavage doses (24 h apart) of Longvida? to Swiss albino mice at 500,1000, or 2000-mg/kg body weight/ day did not cause structural or numerical chromosomal damage in somatic cells in the mammalian erythrocyte micronucleus test. It was therefore concluded that Long-vida? is non-genotoxic.

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