Cancer-Selective Supramolecular Chemotherapy by Disassembly-Assembly Approach

M. T. Jeena; Seongeon Jin; Keunsoo JeongYuri ChoJin Chul KimJeong Hyeon LeeSeokyoung LeeSuk-Won HwangSang Kyu KwakSehoon KimJa-Hyoung Ryu

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Cancer-Selective Supramolecular Chemotherapy by Disassembly-Assembly Approach

机译：Cancer-Selective Supramolecular Chemotherapy by Disassembly-Assembly Approach

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Intramitochondrial supramolecular assembly can be a new therapeuticstrategy for treating cancer because mitochondria are the key for virtuallyall facets of the tumorigenesis. However, the in vivo applications ofmitochondria-targeting molecules are limited due to the positive charge andhydrophobicity that should be possessed by these molecules to penetratethe mitochondrial membrane, which may induce nonspecific serum proteininteractions and normal cell accumulation. Herein, a stimuli-responsivemitochondria-targeting molecule, Mito-SA that forms nano-sized micellesunder physiological conditions is presented. In the aggregated state, thesuccinic amide bonds in Mito-SA are cleaved in response to tumoral pH bystabilizing the transition state through the intermolecular interactions and themicelle disassembles into a mitochondria-targeting parent molecule, Mito-FF.The Mito-FF accumulate inside cancer mitochondria to induce cell death byintra-mitochondrial self-assembly into fiber structures. This tumoral stimuliresponsivedisassembly–assembly approach will provide insight to developmitochondria targeted supramolecular anticancer agent with high tumoralspecificity.

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《Advanced functional materials》 |2022年第52期|2208098.1-2208098.12|共12页
作者
M. T. Jeena; Seongeon Jin; Keunsoo JeongYuri ChoJin Chul KimJeong Hyeon LeeSeokyoung LeeSuk-Won HwangSang Kyu KwakSehoon KimJa-Hyoung Ryu;
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Department of ChemistryUlsan National Institute of Science and Technology (UNIST)Ulsan 44919, Republic of Korea;

Chemical and Biological Integrative Research CenterKorea Institute of Science and TechnologySeoul 02792, Republic of Korea;

Chemical and Biological Integrative Research CenterKorea Institute of Science and TechnologySeoul 02792, Republic of Korea,KU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul 02841, Republic of KoreaDepartment of Energy and Chemical EngineeringUlsan National Institute of Science and Technology (UNIST)Ulsan 44919, Republic of KoreaKU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul 02841, Republic of KoreaDepartment of Energy and Chemical EngineeringUlsan National Institute of Science and Technology (UNIST)Ulsan 44919, Republic of Korea,Department of Chemical and Biological EngineeringKorea University145 Anam-ro, Seoul, Seongbuk-gu 02841, Republic of Korea;

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正文语种英语
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assembly-disassembly; cancer cell death; enhanced specificities; intramitochondrial assemblies; pH stimuli;

Cancer-Selective Supramolecular Chemotherapy by Disassembly-Assembly Approach

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