Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

Cristina Papayannidis; Jacopo Nanni; Gianluca CristianoGiovanni MarconiChiara SartorSarah ParisiLetizia ZannoniRashed SaedEmanuela OttavianiLorenza BandiniNicoletta TestoniCarmen BaldazziVincenza SolliPaolo RicciChiara Di Giovanni BezziRania Abd‐alatifMarta StanzaniStefania PaoliniMichele CavoAntonio Curti

首页> 外文期刊>European Journal of Haematology >Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

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Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

机译：Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

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Abstract Venetoclax (VEN) and hypomethylating agent (HMAs) regimens are emerging as the standard of care for unfit for chemotherapy acute myeloid leukemia (AML) patients, but the safety and feasibility of a total outpatient management have not been fully investigated. Fifty‐nine AML patients with active disease received VEN and HMAs. Nineteen out of 59 (32.2) patients received the first cycle as inpatients, whereas 40/59 (67.8) patients were treated in the outpatient setting. No significant differences were observed with regard to incidence of adverse events (AEs), including tumor lysis syndrome (TLS), and the 30‐day and 60‐day mortality was comparable. Notably, an infectious prophylaxis inspired to that adopted during intensive chemotherapy resulted in a low infection rate with a reduced bacterial infections incidence in out‐ versus hospitalized patients (p?

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来源
《European Journal of Haematology》 |2022年第6期|449-459|共11页
作者
Cristina Papayannidis; Jacopo Nanni; Gianluca CristianoGiovanni MarconiChiara SartorSarah ParisiLetizia ZannoniRashed SaedEmanuela OttavianiLorenza BandiniNicoletta TestoniCarmen BaldazziVincenza SolliPaolo RicciChiara Di Giovanni BezziRania Abd‐alatifMarta StanzaniStefania PaoliniMichele CavoAntonio Curti;
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作者单位

IRCCS Azienda Ospedaliero‐Universitaria di Bologna,Istituto di Ematologia “Seràgnoli”;

Dipartimento di Medicina Specialistica,Università di Bologna;

IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"Assistenza Domiciliare AIL Bologna;

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正文语种英语
中图分类血液及淋巴系疾病;
关键词
acute myeloid leukemia; hospitalization; hypomethylating agents; infections; outpatient; real life; Venetoclax;

Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

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