A Fusion Method Based on Alignment Software with SNP and Indel Detection Methods

Chen Guobing; Tang Chao; Qi JunWang YingShi Xiaolong

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A Fusion Method Based on Alignment Software with SNP and Indel Detection Methods

机译：A Fusion Method Based on Alignment Software with SNP and Indel Detection Methods

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摘要

Background: With the advent of the second-generation sequencing technology, the discovery of sequence alignment and sequence variation is a long-standing challenge. Methods: A method based on general alignment software, SNP, and Indel software tools was proposed in this paper. By comparing the advantages of traditional alignment software, we can produce the best alignment. Results: SNP and Indel detection tools fusion research found that different depth of sequencing effect is different. When the sequence depth reaches a certain value, one of the softwares is selected for testing. Conclusion: Finally, the experimental verification shows that SNP and Indel have certain advantages in comparing the effects of the fusion method.

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来源
《Combinatorial chemistry & high throughput screening》 |2022年第3期|519-527|共9页
作者
Chen Guobing; Tang Chao; Qi JunWang YingShi Xiaolong;
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作者单位

Rongzhi Coll,Chongqing Technol & Business Univ;

Radiat & Canc Biol Lab,Chongqing Univ;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Second-generation sequencing; SNP; indel; fusion research; software tools; sequence alignment; READ ALIGNMENT;

A Fusion Method Based on Alignment Software with SNP and Indel Detection Methods

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