Non-Invasive Transdermal Delivery Systems with Deep Tissue Penetrating Ability for Local ROS-Modulating Chemotherapy

ChengYu Deng; Rong Zhuang; ZhuoYang YingJiasheng TuXianghui XuChunmeng SunLei Jiang

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Non-Invasive Transdermal Delivery Systems with Deep Tissue Penetrating Ability for Local ROS-Modulating Chemotherapy

机译：Non-Invasive Transdermal Delivery Systems with Deep Tissue Penetrating Ability for Local ROS-Modulating Chemotherapy

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摘要

Cutaneous melanoma is the deadliest malignant skin cancer due to its poorprognosis, rapid local growth, and high metastasis. Transdermal administrationfor local drug delivery would be one of the most appropriate therapyregimens. However, promoting drug penetration into deep tumor tissueand maintaining the balance of redox homeostasis during the antitumortreatment to inhibit melanoma progression remains a great challenge inmelanoma treatment. Herein, non-invasive transdermal delivery systemsare reported for melanoma treatment, which is composed of biocompatiblehydrogel and penetrating nanocarriers. Highly penetrating nanocarriers canco-deliver paclitaxel and coenzyme Q10 for inhibiting melanoma and reducingside effects, which are attributed to drug encapsulation, deep tissue penetration,high cellular uptake, and organelle targeting. More importantly, biocompatiblehydrogels serve as nanocarriers platforms for melanoma location andtransdermal delivery. This hierarchical nanoparticle-hydrogel system achieveshigh-efficiency non-invasive transdermal delivery for inhibiting melanoma,blocking adverse effects, and restraining melanoma development.

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《Advanced functional materials》 |2022年第46期|2206876.1-2206876.10|共10页
作者
ChengYu Deng; Rong Zhuang; ZhuoYang YingJiasheng TuXianghui XuChunmeng SunLei Jiang;
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作者单位

Department of PharmaceuticsSchool of PharmacyChina Pharmaceutical University24 Tong Jia Xiang, Nanjing 210009, P. R. China;

NMPA Key Laboratory for Research and Evaluation of PharmaceuticalPreparations and Excipients24 Tong Jia Xiang, Nanjing 210009, P. R.;

Department of PharmacyCollege of BiologyHunan UniversityChangsha, Hunan 410082, P. R. China;

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正文语种英语
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deep tissue-penetrating deliveries; non-invasive; ROS-modulating chemotherapies; transdermal delivery systems;

Non-Invasive Transdermal Delivery Systems with Deep Tissue Penetrating Ability for Local ROS-Modulating Chemotherapy

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