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首页> 外文期刊>Journal of applied toxicology >Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis
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Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis

机译：Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis

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Abstract Vinyl chloride (VC) is a common industrial organic chlorine and environmental pollutant. In recent years, the dietary structure of residents especially Chinese has gradually shifted to western dietary patterns. VC aggravates dietary fatty acid‐induced hepatic steatosis, but its mechanism is still unclear. And if the risk factors for steatosis persist, more severe diseases such as fibrosis and cirrhosis will occur. Therefore, we studied the effects and mechanisms of VC (160 and 800?mg/m3) and its metabolite (chloroacetaldehyde, 2.25, 4.5, and 9?μM) on hepatic steatosis of high‐fat diet (HFD)‐fed mice and palmitic acid (PA, 100?μM) treated HepG2 cells. Liver and serum biochemical indicators and pathological staining of the liver showed that the hepatic steatosis of VC combined with HFD groups was more severe than that of single‐exposure groups (HFD group, low‐dose VC group, and high‐dose VC group). Moreover, VC enhanced HFD‐induced oxidative stress (OS) and endoplasmic reticulum stress (ERS) and further upregulated the expression of sterol regulatory element‐binding protein 1 (SREBP‐1) and FAS. Besides, antioxidants and ERS inhibitors reduced the steatosis of HepG2 cells induced by VC metabolites and PA. These results suggest that VC exposure can enhance the degree of hepatic steatosis in HFD‐fed mice. VC combined with HFD led to OS and ERS and upregulated the expression of de novo lipogenesis‐related proteins, which may be related to the occurrence of hepatic steatosis. And the increased expression of CYP2E1 induced by VC combined with HFD may be the cause of OS.

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