LncRNA FAM138B inhibits the progression of non-small cell lung cancer through miR-105-5p

Gao Jing; Pan Tinghong; Wang HuiWang ShuaiChai JinJin Chengyan

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LncRNA FAM138B inhibits the progression of non-small cell lung cancer through miR-105-5p

机译：LncRNA FAM138B inhibits the progression of non-small cell lung cancer through miR-105-5p

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摘要

As a type of lung cancer, non-small cell lung cancer (NSCLC) has the characteristics of high mortality and high recurrence rate, which poses a great threat to human life and health. Due to the high risk of surgical treatment and the slow recovery of wounds, non-coding RNAs, especially lncRNAs are used as new potential clinical prognostic markers to prevent and treat cancer in advance. This study aims to explore the role of FAM138B in NSCLC and its possibility as a prognostic biomarker. Real-timequantitative polymerase chain reaction (RT-qPCR) was used to detect the expression and overexpression level of lncRNA FAM138B (FAM138B) in cells and tissues. The CCK-8, Transwell migration and invasion methods were performed to observe the cell transfection.The interaction between FAM138B and miR-105-5p was predicted by the bioinformatics tool starBase v2.0, and verified by the luciferase reporter gene experiment. Kaplan-Meier and Cox regression analyses were used to determine the prognostic significance of FAM138B in NSCLC. The expression of FAM138B is down-regulated in NSCLC cells and tissues. Overexpression of FAM138B can inhibit the expression level of miR-105-5p in NSCLC cells, and the ability of NSCLC cells to proliferate, migrate and invade is downregulated. FAM138B targets miR-105-5p, and there is a negative correlation between FAM138B and miR-105-5p. It is confirmed that FAM138B inhibits the progression of NSCLC by targeting miR-105-5p and can be a potential prognostic biomarker for NSCLC.

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来源
《Cell cycle》 |2023年第7期|808-817|共10页
作者
Gao Jing; Pan Tinghong; Wang HuiWang ShuaiChai JinJin Chengyan;
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作者单位

Dept Thorac Surg,Yidu Cent Hosp Weifang;

Jilin University,Second Hosp Jilin Univ;

Dept Pharm,Second Hosp Jilin UnivDept Thorac Surg,Second Hosp Jilin Univ;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
FAM138B; miR-105-5p; NSCLC; prognostic biomarkers; EXPRESSION; PROLIFERATION; EPIDEMIOLOGY; MIGRATION; DIAGNOSIS; INVASION; PROMOTES; GROWTH;

LncRNA FAM138B inhibits the progression of non-small cell lung cancer through miR-105-5p

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