Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

Russell J. Erickson; David R. Mount; Terry L. HighlandJ. Russell HockettDale J. HoffCorrene T. JensonTeresa J. Norberg‐KingBrandy Forsman

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Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

机译：Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

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Mathematical models are presented for the acute median lethal concentrations of major geochemical ions (Na~+,K~+, Ca~（2+）, Mg~（2+）, Cl~?, SO_4~(2?), HCO_3~?/CO_3~(2?)) to fathead minnows (Pimephales promelas), based on an extensive series ofexperiments presented in a companion article. Toxicity relationships across different dilution waters, individual salts, and saltmixtures suggest six independent mechanisms of toxicity to consider in modeling efforts, including Mg/Ca‐specific toxicity,osmolarity‐related toxicity, SO4‐specific toxicity, K‐specific toxicity, effects of high pH/alkalinity, and a multiple ion‐relatedtoxicity at low Ca distinct from the other mechanisms. Models are evaluated using chemical activity‐based exposure metricspertinent to each mechanism, but concentration‐based alternative models that are simpler to apply are also addressed.These models are compared to those previously provided for Ceriodaphnia dubia, and various issues regarding theirapplication to risk assessments are discussed.

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《Environmental toxicology and chemistry /》 |2022年第9期|2095-2106|共12页
作者
Russell J. Erickson; David R. Mount; Terry L. HighlandJ. Russell HockettDale J. HoffCorrene T. JensonTeresa J. Norberg‐KingBrandy Forsman;
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作者单位

Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Ecology, US Environmental Protection Agency, Office of Research andDevelopment, Duluth, Minnesota, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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关键词
Aquatic toxicology; Major geochemical ions; Pimephales promelas; Fathead minnow; Toxicity mechanisms; Mixture toxicity; Mathematical models;

Acute Toxicity of Major Geochemical Ions to Fathead Minnows (Pimephales promelas): Part B—Modeling Ion Toxicity

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